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Fertility preservation, like sperm or egg freezing, is worth discussing before starting therapies that may reduce reproductive capacity, especially in youth.
Transdermal estradiol may be preferred in patients with high triglycerides or gallbladder concerns, reflecting different hepatic first-pass effects than oral forms.
Acne or oiliness from testosterone may be managed with skincare, dose timing, or adjunct medications, balancing goals with comfort and self-image.
In perimenopause, low-dose hormone therapy may smooth fluctuating symptoms, while nonhormonal strategies can complement care for a holistic approach.
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