When picking or editing a gaming or anime PFP, focus on a clear silhouette and...

https://purepfp.com/why-bold-game-characters-remain-recognisable-in-tiny-profile-icons/

When picking or editing a gaming or anime PFP, focus on a clear silhouette and crop tightly on the face so details don’t get lost when it shrinks. Keep the background simple, and avoid text or clutter